There is a wealth of research showing the efficacy and safety of Colsotrum and of Hyper Immunized Colostrum.  Below is some  examples of such research:
 

Bitzan MM, Gold BD, Philpott DJ, et al. (1998). Inhibition of Helicobacter pylori and Helicobactor mustelae binding to lipid receptors by bovine colostrum. The Journal of Infectious Diseases. 177:955-961.

Cavalli-Sforza LT, Strata A. (1987). Double-blind study on the tolerance of four types of milk in lactose malabsorbers. Human Nutrition: Clinical Nutrition. 40C:19-30.

McConnell MA, Brooks HJL, Borissenko MB, Buchan GA. A comparative study of immunoglobulin levels and anti-inflammatory activity in four milk products. Journal of Dairy Science. Publication forthcoming.

Warny M, Fatima A, Bostwick E, et al. (1998) Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralizing activity after passage through the human stomach and small intestine. Gut. 44(2):212-7.

Wieczorek Z, Zimecki M, Janusz M, Staroscik K, Lisowski J. (1979) Proline-rich polypeptide from ovine colostrum: its effect on skin permeability and on the immune system. Immunology. 36:879-881.

Yamamoto A, Wada O, Suzuki H. (1987) Purification and properties of biologically active chromium complex from bovine colostrum. American Institute of Nutrition. 118(1):39-45.

Brussow H, Hilpert H, Walther I, Sidoti J, Mietens C, Bachmann P. Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis. J Clin Microbiol 1987; 25(6):982-986.

Buckley J, Abbott M, Martin S, Brinkworth G, Whyte P. Effect on an oral bovine colostrum supplement (intact™) on running performance. Abstract from: 1998 Australian conference of science and medicine in sport, Adelaide, South Australia, October 1998.


Ebina T, Sato A, Umezu K, Ishida N, Ohyama S, Oizumi A, Aikawa K, Katagiri S, Katsushima N, Imai N, Kitaoka S, Suzuki H, Konno T. Prevention of rotavirus infection by oral administration of cow colostrum containing anti-human rotavirus antibody. Med Microbiol Immunol 1985; 174: 177-185.



Francis GL, Upton FM, Ballard FJ, McNell KA, Wallace JC. Insulin-like growth factors 1 and 2 in bovine colostrum. Sequences and biological activities compared with those of a potent truncated form. Biochem J 1988; 251:95-103.


Korhonen H, Syväoja E-L, Ahola-Luttila H, Sivelä S, Kopola S, Husu J, Kosunen TU. Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobacter pylori. J Appl Bacteriol 1995; 78:655-662.



Lissner R, Thurmann PA, Merz G, Karch H. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows (Lactobin) to healthy volunteers. Int J Clin Pharmacol Ther 1998; 36: 239-245.


Okhuysen PC, Chappell CL, Crabb J, Valdez LM, Douglass ET, DuPont HL. Prophylactic effect of bovine anti-Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum. Clin Infect Dis 1998; 26:1324-1329.



Pakkanen R, Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J 1997; 7: 285-297.

Petshow BW, Talbott RD. Reduction in virus-neutralizing activity of a bovine colostrum immunoglobulin concentrate by gastric acid and digestive enzymes. J Ped Gastroenterol Nutr 1994; 19:228-235.

Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999; 44: 653-658.

Pritchett LC, Gay CC, Besser TE, Hancock DD. Management and production factors influencing immunoglobulin G1 concentration in colostrum from Holstein cows. J Dairy Sci 1991; 74: 2336-2341.

Rogers M-L, Goddard C, Regester GO, Ballard FJ, Belford DA. Transforming growth factor ? in bovine milk: concentration, stability and molecular mass forms. J Endocrinol 1996; 151:77-86.


Sarker SA, Casswall TH, Mahalanabis D, Alam NH, Albert MJ, Brussow H, Fuchs GJ, Hammerström L. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J 1998; 17:1149-1154.
Scammell AW. Liquid colostrum for dairy products. Patent WO 97/16977 (int publ numb). 1997.

Warny M, Fatimi A, Bostwick EF, Laine DC, Lebel F, LaMont JT, Pothoulakis C, Kelly CP. Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxine neutralising activity after passage through the human stomach and small intestine. Gut 1999; 44:212-217.


Zhihui Z, Kuixiong S, Bixia P, Lunan S, Xiuxian X, Hong H. A study on the anti-aging effect of bovine colostrum extract in the elderly. Acta Nutrimenta Sinica 1994; 16:169-173.


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Acosta-Altamirano, G., et al., Anti-amoebic properties of human colostrum. Adv. Exp. Med. Biol. 1987. 216B: p.1347-1352.

Dwyer, J. M. Manipulating the Immune System with Immune Globulin. New Engl. J. Med. 326(2):107-116. Jan. 9, 1992.

Francis, G. L., et al., Purification and partial sequence analysis of insulin-like growth factor-l (IGF-1) from bovine colostrum. Biochem. J. 1986. 233: p. 207-213.

Francis, G. L., et al., Insulin-like growth factors-l (IGF-1) and 2 (IGF-2) in bovine colostrum. Biochem. J. 1988. 251:p. 95-103.

Janusz, M. et ad. Immunoregulatory Properties of Synthetic Peptides: Fragments of a Proline-rich Polypeptide from Bovine Colostrum. Molecular Immunology. 24(10): 1029-1031. 1987

Kim, K., et al., In vitro and in vivo neutralizing activity of human colostrum and milk against purified toxins A and B of Clostridium difficile. T. Infect. Dis. 1985. 150: p. 57-61.

Nord, J. et al. Treatment with Bovine Hyperimmune Colostrum of Cryptosporidial Diarrhea in AIDs Patients. AIDS. 4(6):581-584. June 1990.

Ogra, P. et al. Colostrum Derived Immunity and Maternal Neonatal Interaction. Annals NY Acad. Sci. 409:82-92. 1983.

Palmer,E.L. et al. Antiviral Activity of Colostrum and Serum Immunoglobulins A and G. J. Med. Virol. 5:123-129. 1980.

Stephan, W., et al., Antibodies from colostrum in oral immunotherapy. J. Clin. Chem. Clin. Biochem. 1990. 28: p. 19-23.

Ungar, B. L. P., et al., Cessation of Cryptosporidium-associated diarrhea in AIDS patient after treatment with hyperimmune bovine colostrum. Gastroenterology 1990. 98: p. 486-489.

Francis, G.L. et. al. "Insulin-like growth factors 1(IGF-1) and 2(IGF-2) in bovine colostrum" Biochemistry Journal Vol. 251 (pp95-103), 1988.

Palmer, E.L. et. al. "Antiviral Activity of Colostrum and Serum Immunoglobulins A and G". Medical Virology, Vol. 5 (pp123-129), 1980.

 
Wilson, D.C. and James, N.D. "Immune System Breakthrough: Colostrum" Journal Of Longevity, Vol. 4 (p2), 1998.



Acosta-Altamirano, G, et al. Antiamoebic properties of human colostrum. Advances in Experimental Medicine and Biology 216B:1347-1352 (1987). 

Akisu, C, et al. Effect of human milk and colostrum on Entamoeba histolyica. World Journal of Gastroenterology 10(5):741-742 (2004).

Armogida, SA, Yannaras, NM, Melton, AL, Srivastava, MD. (2004). Identification and quantification of innate immune system mediators in human breast milk. Allergy and Asthma Proceedings 25(5):297-304.

Blach-Olszewska, Z, Janusz, M. Stimulatory effect of ovine colostrinine (a proline-rich polypeptide) on interferons and tumor necrosis factor production by murine resident peritoneal cells. Archivum immunologiae et therapiae experimentalis (Warszava) 45(1):43-47 (1997).

Boesman-Finkelstein, M., et al., Passive oral immunization of children. Lancet. 1989. 49: p. 1336.

Boldogh, I, Liebenthal, D, Hughes, TK, Juelich, TL, Georgiades, JA, Kruzel, ML, Stanton, GJ. Modulation of 4HNE-mediated signaling by proline-rich peptides from ovine colostrum. Journal of Molecular Neuroscience 20(2):125-134 (2003).

Brüssow, H., et al. Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis. Journal of Clinical Microbiology 25(6):982-986 (1987). 

Cesarone, MR, Belcaro, G, Di Renzo, A, Dugall, M, Cacchio, M, Ruffini, I, Pellegrini, L, Del Boccio, G, Fano, F, Ledda, A, Bottari, A, Ricci, A, Stuard, S, Vinciguerra, G. (2007) Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino. Clinical and Applied Thrombosis/Hemostasis 13(2):13-6. 

De Vinci, C, Levine, PH, Pizza, G, Fudenberg, HH, Orens, P, Pearson, G, Viza, D. Lessons from a pilot study of transfer factor in chronic fatigue syndrome. Biotherapy 9(1-3):87-90 (1996).


Dwyer, J. M. Manipulating the Immune System with Immune Globulin. New Engl. J. Med. 326(2):107-116. Jan. 9, 1992.

Ebina, T, et al. Passive immunizations of suckling mice and infants with bovine colostrum containing antibodies to human rotavirus. Journal of Medical Virology 38:117-123 (1992).  Funatogawa, K, et al. Use of immunoglobulin enriched bovine colostrum against oral challenge with enterohaemorrhagic Eschericia coli O157:H7 in mice. Microbiology and Immunology 46(11):761-766 (2002). 

Hagiwara, K, et al. Oral administration of IL-1 beta enhanced the proliferation of lymphocytes and the O(2)(-) production of neutrophil in newborn calf. Veterinary Immunology and Immunopathology 81(1-2):59-69 (2001). 


Inglot, A.D, Janusz, M, Lisowski, J. Colostrinine: a proline-rich polypeptide from ovine colostrum is a modest cytokine inducer in human leukocytes. Archivum immunologiae et therapiae experimentalis (Warszava) 44(4):215-224 (1996).

Janusz, M, Staroscik, K, Zimecki, M, Wieczorek, Z, Lisowski, J. A proline-rich polypeptide (PRP) with immunoregulatory properties isolated from ovine colostrum. Murine thymocytes have on their surface a receptor specific for PRP. Archivum immunologiae et therapiae experimentalis (Warszava) 34(4):427-436 (1986).

Janusz, M, Lisowski, J. Proline-rich polypeptide (PRP)--an immunomodulatory peptide from ovine colostrum. Archivum immunologiae et therapiae experimentalis (Warszava) 41(5-6):275-279 (1993).

Julius, MH, et al. A colostral protein that induces the growth and differentiation of resting B lymphocytes. Journal of Immunology 140:1366-1371 (1988).

Janusz, M, Wieczorek, Z, Spiegel, K, Kubik, A, Szewczuk, Z, Siemion, I, Lisowski, J. Immunoregulatory properties of synthetic peptides, fragments of a proline-rich polypeptide (PRP) from ovine colostrum. Molecular Immunology 24(10):1029-1031 (1987).

 
Kruzel, ML, Janusz, M, Lisowski, J, Fischleigh, RV, Georgiades, JA. Towards an understanding of biological role of colostrinin peptides. Journal of Molecular Neuroscience 17(3):379-389 (2001).
Kubis, A, Marcinkowska, E, Janusz, M, Lisowski, J. Studies on the mechanism of action of a proline-rich polypeptide complex (PRP): effect on the stage of cell differentiation. Peptides 26(11):2188-2192 (2005).

Khazenson L.B., et al. "[Activity of bovine colostral IgG in the human digestive tract]." Zh Mikrobiol Epidemiol, Immunobiol, 1980;9:101-106.

Korhonen, H, et al. Bovine milk antibodies for health. British Journal of Nutrition 84(Suppl.1):S135-S146 (2000). Bovine colostrum provides safe, effective protection against many pathogens. 

Ogra, P. et al. Colostrum Derived Immunity and Maternal Neonatal Interaction. Annals NY Acad. Sci. 409:82-92. 1983.

Palmer, EL, et al. Antiviral activity of colostrum and serum Immunoglobulins A and G. Journal of Medical Virology 5:123-129 (1980). Virus-specific IgA was discovered in colostrum, including anti-polio antibody.

Pineiro, A.,et al. "Trypsin inhibitor from cow colostrum., Isolation, electrophoretic characterization and immunologic properties." Biochem Biophys Acta (Amsterdam), 1975;379(1): 201-206.

Lisowski, J, Wieczorek, Z, Janusz, M, Zimecki, M. Proline-rich polypeptide (PRP) from ovine colostrum. Bi-directional modulation of binding of peanut agglutinin, resistance to hydrocortisone, and helper activity in murine thymocytes. Archivum immunologiae et therapiae experimentalis (Warszava) 36(4):381-393 (1988).

Staroscik, K, Janusz, M, Zimecki, M, Wieczorek, Z, Lisowski, J. Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties. Molecular Immunology 20(12):1277-1282 (1983).

Siemion, IZ, Folkers, G, Szewczuk, Z, Jankowski, A, Kubik, A, Voelter, W. Peptides related to the active fragment of "proline rich polypeptide", an immunoregulatory protein of the ovine colostrum. Spectroscopic and computer modeling studies. International Journal of Protein and Peptide Research 36(6):506-514 (1990).


Solomons, N. W., Modulation of the immune system and the response against pathogens with bovine colostrum concentrates. European Journal of Clinical Nutrition 56(Suppl.3):S24-S28 (2002).

Stoff, J. A., The Use of Dialyzable Bovine Colostrum Extract in Conjunction with a Holistic Treatment Model for Natural Killer Cell Stimulation in Chronic Illness. Obtained by Matol Botanical International (1-800-363-1890).

Stoff, J, et al. An Examination of Immune Response Modulation in Humans by Ai/E¹º® Utilizing A Double Blind Study. Townsend Letter April, 2002. Peptides in a colostrum extract increased levels of immune activity in healthy subjects.

Stephan, W., et al., Antibodies from colostrum in oral immunotherapy. J. Clin. Chem. Clin. Biochem. 1990. 28: p. 19-23.

Sabin, A. & Fieldsteel, A.H. "Antipoliomyelitic activity of human and bovine colostrum and milk." Pediatrics, 1962:105-115.

Sabin, AB. Anti-poliomyelitic substance in milk from human beings and certain cows. Journal of Diseases of Children 80:866-870 (1950). 

Solomons, NW. Modulation of the immune system and the response against pathogens with bovine colostrum concentrates. European Journal of Clinical Nutrition 56(Suppl.3):524-528 (2002). 

Stephan, W, et al. Antibodies from colostrum in oral immunotherapy. Journal of Clinical Chemistry and Clinical Biochemistry 28:19-23 (1990). 

Sirota, L, et al. Effect of human colostrum on interleukin-2 production and natural killer cell activity. Archive of Diseases in Childhood: Fetal and Neonatal Edition 72(3):F99-102 (1995).

Staroscik, K, Janusz, M, Zimecki, M, Wieczorek, Z, Lisowski, J. Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties. Molecular Immunology 20(12):1277-1282 (1983).

Widiasih, DA, et al. Passive transfer of antibodies to Shiga toxin-producing Eschericia coli O26, O111 and O157 antigens in neonatal calves by feeding colostrum. Journal of Veterinary Medicine 66(2):213-215 (2004). 

Zimecki, M, Janusz, M, Staroscik, K, Wieczorek, Z, Lisowski, J. Immunological activity of a proline-rich polypeptide from ovine colostrum. Archivum immunologiae et therapiae experimentalis (Warszava) 26(1-6):23-29 (1978).

Zimecki, M, Artym, J. Therapeutic properties of proteins and peptides from colostrum and milk. Post?py Higieny i Medycyny Doswiadczalne j 59:309-323 (2005).

Zimecki, M, Staroscik, K, Janusz, M, Lisowski, J, Wieczorek, Z. The inhibitory activity of a proline-rich polypeptide (PRP) on the immune response to polyvinylpyrrolidone (PVP). Archivum immunologiae et therapiae experimentalis (Warszava) 31(6):895-903 (1983).

For Additional Links: www.scholar.google.com keywords: Colostrum, Immune System



Bocci V, Von Bremen K, Corradeschi F, Luzzi E, Paulesu L. (1991) What is the role of cytokines in human colostrum? Journal of Biological Regulators and Homeostatic Agents. 3:121-124.

Boesman-Finkelsein M, Walton NE, Finkelstein RA. (1989) Bovine lactogenic immunity against cholera toxin-related enterotoxins and Vibrio cholerae outer membranes. Infection and Immunity. 57:1227-1234.

Boesman-Finkelstein M. and Finkelstein R. (1989) Passive oral immunization of children. Lancet. 2(8675):1336.

Bogstedt AK, Johansen K, Hatta H, et al. (1996) Passive immunity against diarrhea. Acta Paediatr. 85:125-128.

Davidson G, Whyte P, Daniels E, et al. (1989) Passive immunization of children with bovine colostrum containing antibodies to human rotavirus. Lancet. 2(8665):709-12.

Dichtelmuller W, Lissner R. (1990) Antibodies from colostrum in oral immunotherapy. Journal of Clinical Biochemistry. 28:19-23.

Ebina T, Umezu K, Ohyama S, et al. (1983) Prevention of rotavirus infection by cow colostrum containing antibody against human rotavirus. Lancet. 2(8357):1029-30.

Francis, G. L., et al., Purification and partial sequence analysis of insulin-like growth factor-l (IGF-1) from bovine colostrum. Biochem. J. 1986. 233: p.207-213.

Francis, G. L., et al., Insulin-like growth factors-l (IGF-1) and 2 (IGF-2) in bovine colostrum. Biochem. J. 1988. 251:p. 95-103.

Hanson LA, Ahlstedt S, Andersson B, et al. (1983) Mucosal Immunity. Annals New York Academy of Sciences. 83:1-20.

Hilpert H, Brussow H, Mietens C, Sidoti J, Lerner L, Werchau H. (1987) Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. Journal of Infectious Diseases. 156:158-166.

Hirmo S, et al. (1998) Characterization of Helicobacter pylori interactions with sialylglycoconjugates using a resonant mirror biosensor. Analytical Biochemistry. 257:63-6.
 
Honorio-Franca A, Carvalho M, Isaac L, Trabulsi l, Carneiro-Sampaio M. (1997) Colostral mononuclear phagocytes are able to kill enteropathogenic Escherichia coli opsonized with colostral IgA. Scandavian Journal of Immunology. 46:59-66.

Huppertz H, Rutkowski S, Busch D, Eisebit R, Lissner R, Karch H. (1999). Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin producing E.coli, and E-coli expressing intimin and hemolysin. Journal of Pediatric Gastroenterology and Nutrition. 29:452-456 (1999).

Janusz M, Lisowski J. (1993) Proline-rich polypeptide (PRP) - an immunomodulatory peptide from ovine colostrum. Archivum Immunologiae et Therapiae Experimentalis. 41:275-279.

 
Kelly CP, et al. (1996) Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotixicity of C. difficile toxins. Antimicrobial Agents and Chemotherapy. 40:373-379.

 
Khazenson L, Gennad'eva T, Roshchin V, Krasheniuk A, Semenova N. (1980) Activity of bovine colostral IgG in the human digestive tract. ZH Mikrobiol Epidemiol Immunobiol. 9:101-106.

 
Korthonen H, Suvaoja EL, Ahola-Luttilia H, et al. (1995) Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobactor pylori. Journal of Applied Bacteriology. 78:655-662.

 
LeFranc-Millot C, Vercaigne-Marko D, Wal J. -M, et al. (1996) Comparison of the IgE titers to bovine colostral G immunoglobulins and the F(ab')2 fragments in sera of patients allergic to milk. Int Arch Allergy Immunol. 110:156-162.

Lissner R, Thurmann P, Merz G, Karch, H. (1998) H. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows to healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 36:239-245.

McConnell, M. A., Buchan, G. A. A., Borissenko, M. V., Brooks, H. J. L. (2001). A Comparison of IgG and IgG1 Activity in an Early Milk Concentrate from Non-Immunised Cows and a Milk from Hyperimmunised Animals. Food Research International 34 (2001) 255 - 261.

Michalek SM, McGhee JR, Babb JL. (1978) Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to rats. Infection and Immunity. 19:217-224.

Parodi PW. (1996) Milk fat components: possible chemopreventive agents for cancer and other diseases. The Australian Journal of Dairy Technology. 51:24-32.

Petschow B, Talbott R. (1994). Reduction in virus-neutralizing activity of a bovine colostrum immunglobulin concentrate by gastic acid and digestive enzymes. Journal of Pediatric Gastroenterology and Nutrition. 19:228-235.

Plettenberg A, Stoehr A, Stellbrink J, Albreacht H, Meigel W. (1993) A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea. Clinical Investigator. 71:42-45.

Pincus C, Nussenweig V. (1971) Regulation of the Immune Response: Suppressive and enhancing effects of passively administered antibody. Journal of Experimental Medicine. 133:987-1003.

Pironi L, Miglioli M, Ruggeri E, et al. (1990) Relationship between intestinal permeability to EDTA and inflammatory activity in asymptomatic patients with Crohn's disease. Digestive Diseases and Sciences. 35(5):582-8.

Quigley JD, Martin KR, Dowlen HH, Wallis LB, Lamar K. (1994) Immunoglobulin concentration, specific gravity, and nitrogen fractions of colostrum from Jersey cattle. Journal of Dairy Science. 77:264-269.

Rautiainen E. (1998) The prevalence of Mycoplasma hyopneumoniae in pig herds in western Finland based on the demonstration of antibodies in colostrum by ELISA. Acta Vet Scand. 39:325-330.

Ritchie D, Becker E. (1994) Update on the management of intestinal cryptosporidiosis in AIDS. The Annals of Pharmacotherapy. 28:767-778.

Saif L, Smith K. (1985) Enteric viral infections of calves and passive immunity. Journal of Dairy Science. 68:206-228.

Sandholm M, Honkanen-Buzalski T. (1979) Colostral trypsin-inhibitor capacity in different animal species. Acta Vett. Scand. 20:469-476.

Sarker S, Casswall T, Mahalanabis M, et al. (1998) Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatric Journal of Infectious Disease. 17:1149-54.

Savilahti E, Tainio VM, Salmenpera L, Arjomaa P, Kallio M, Perheentupa J, Siimes MA. (1991) Low colostral IgA associated with cow's milk allergy. Acta Pediatr Scan. 80:1207-1213.

Selo I, Clement G, Bernard H, et al. (1999) Allergy to bovine B-lactoglobulin: specificity of
human IgE to tryptic peptides. Clinical and Experimental Allergy. 29:1055-1063.

Shearman D. (1972) The demonstration and function of antibodies in the gastrointestinal tract. Gut. 13(6):483-99.

Siber G. (1992) Immune globulin to prevent nosocomial infection. New England Journal of Medicine. 327(4):269-71.

Stephen W, Dichtelmuller H, Lissner R. (1990) Antibodies from colostrum in oral immunotherapy. Journal of Chemical Clinical Biochemistry. 28:19-23.

Staroscik K, Janusz M, Zimecki M, Wieczorek Z, Lisowski J. (1983) Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties. Molecular Immunology. 12:1277-1282.

Swarbrick ET. (1992) The handling of ingested antigens. Am J Trop Med Hyg. 47(3):276-83.
Tacket CO, Binion SB, Bostwick E, Losonsky G, Roy MJ, Edelman R. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Am. J. Trop. Med. Hyg. 47:276-283 (1992).

Takahashi, T. and et al. (1998) Effects of Orally Ingested Bifidobacterium longum on the Mucosal IgA response of Mice to Dietary Antigens. Biosci Biotechnol Biochem. 62(1):10-5.

Tejada-Simon M, Lee J, Ustunol Z, Pestka J. (1999) Ingestion of yoghurt containing lactobacillus acidophilus and bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice. Journal of Dairy Science. 82:649-660.

Tyler J, Stevens B, Hostetler D, Holle J, Denbigh J. (1999) Colostral immunoglobulin concentrations in holstein and guernsey cows. American Journal of Veterinary Research. 60(9):1136-9

Tzipori S, Roberton D, Chapman C. (1986) Remission of diarrhea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrum. British Medical Journal. 293(6557):1276-7.

Ulcova-Gallova Z, Fialova P, Krauz V. (1994) Immunologic factors in human colostrum and milk. Casopis Lekaru Ceskych. 133:275-276.

Ungar BLP, Ward DJ, Fayer R, Quinn CA. (1990) Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterology. 98:486-489.

Veselsky L, Cechova D, Jonakova V. (1978) Secretion and Immunochemical Properties of the Trypsin Inhibitor from Bovine Colostrum. Hoppe-Seyler's Z. Physiol. Chem. 359:873-878.

Waldman RH, Stone J, Lazzell V, et al. (1983) Oral route as method for immunizing against mucosal pathogens. Ann N Y Acad Sci. Jun 30;409:510.

Walker M. (1999) Bovine colostrum offers broad-spectrum benefits for wide-ranging ailments. Medical Journalist Report of Innovative Biologics: Townsend Letters for Doctors and Patients. 74-80.



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Chaumeil C, Liotet S, Kogbe O. (1994) Treatment of severe eye dryness and problematic eye lesions with enriched bovine colostrum lactoserum. Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Adv Exp Med Biol. 350:595-9.

Clark, Daniel G. and Wyatt, Kaye. Colostrum, Life¹s First Food. Salt Lake City:CNR Publications. 1996.

Groziak, SM, Miller, GD. Natural bioactive substances in milk and colostrum: effects on the arterial blood pressure system. British Journal of Nutrition 84(Suppl.1):S119-S125 (2000). Consumption of milk and milk products can produce a significant decrease in blood pressure in hypertensive patients.

Goebel, A, et al. Human pooled immunoglobulin in the treatment of chronic pain syndromes. Pain Medicine 3(2):119-127 (2002). Intravenous treatment with pooled IgG from colostrum was shown to be of benefit to patients suffering chronic pain due to fibromyalgia, spinal pain, complex regional pain syndrome (CRPS), peripheral neuropathic pain, and atypical odontalgia or facial pain without serious side effects. All patients had failed to respond to established pain treatment protocols.


Julius; Janusz; Lisowski, "A Colostral Protein (PRP) That Induces the Growth and Differentiation of Resting B Lymphocytes," J. of Immunology. 40:1366-71, 1988.

Korhonen, H, Pihlanto, A. (2007). Technological options for the production of health-promoting proteins and peptides derived from milk and colostrum. Current Pharmaceutical Design 13(8):829-43. Review of current and potential applications of colostrum and milk proteins for human nutrition and promotion of human health.


Staroscik, Krystyna; et al. "Immunologically Active Nonapeptide Fragment of a Proline-Rich Polypeptide from Bovine Colostrum: Amino Acid Sequence and Immuno-Regulatory Properties," Molecular Immunology. 20(12):1277-82, 1983.

For Additional Links: www.scholar.google.com keywords: Colostrum, Immune modulation